Research

Biocomputing and Biohybrid Neural Interfaces

I develop biohybrid systems that combine living cells with silicon technology to create new ways of computing, fabricating, and interfacing within in-vitro and in-vivo setings. My research brings together bioprinting, neuroengineering, and synthetic biology to build experimental models of brain-like tissue that can process information, adapt to changes, and support therapeutic functions.

Using tools like AI-driven Digital Twins , 3D & 4D bioprinting , multi-electrode arrays , and wireless biohybrids , my team explores how biological systems make decisions and how we can guide them. Our goal is to create living systems that can support drug delivery, tissue repair, and new forms of bio-electronic communication—always with a strong focus on biosafety , personalization , and biosecurity .

Research Themes

Computing Biohybrids

We engineer living neural substrats to perform logic operations and decision-making tasks. Our bio-computation platforms implement Boolean logic, classification, and memory functions through both genetic and electrophysiological mechanisms. Using AI-guided modelling and multi-electrode interfacing, we validate these circuits in real-time and adapt them for applications in closed-loop therapeutics, diagnostics, and biologically inspired machine intelligence.

Bioprinting and Biofabrication

Our work in 4D bioprinting creates smart, adaptive scaffolds that not only support neural tissue growth but also integrate sensing, computation, and actuation capabilities. By leveraging stimuli-responsive materials and high-resolution printing, we design living constructs that evolve over time, vascularise, and modulate therapeutic release. We aim for long-term functionality, biocompatibility, and seamless integration with both biological systems and external devices.

Wireless Neural Interfaces

To connect living systems with machines, we build wireless, battery-less interfaces that operate through multiphysical communication. These interfaces power and interrogate embedded biomaterials, cells or tissue constructs non-invasively, enabling real-time feedback and multi-channel neural modulation. This is our vision for scalable, implantable systems and bio-electronic networks rooted in the AI-driven wireless communication paradigm.

Toolkits

AI Digital Twins

AI-driven Digital Twins of living constructs for modeling and predictive analytics.
Used in MSCA-IF STOICISM and our IEEE T-MBMC paper on multiscale digital twins for pharmacology.

3‑D & 4‑D Bioprinting

Customised, stimuli-responsive bioinks and scaffolds for dynamic, evolving tissue architectures.
Developed in UKRI BBSRC IAA and Innovate UK KTP with iMakr.

Multi‑Electrode Arrays

Microcircuit spatiotemporal resolution for precise neuroelectronic interfacing.
Implemented using Axion MEA systems and explored in our Royal Society Open Science paper on neuron–astrocyte network desynchronization.

Wireless Biohybrids

multiphysical links to power and interrogate biohybrids in real time.
Advanced through the EU FET-Open GLADIATOR project and our IEEE TMBMC paper on ultrasonic implants.

Funding History

Role Funding Details Years
PI UKRI BBSRC IAA Engagement Award – Optimisation of exosome-based therapies from 3D BioPrinted stem cell structures 2023-2024
Co-I UKRI BBSRC Pioneers Award – ROS signaling in plants: Are we missing a fundamental pathway? 2024-2026
PI InnovateUK Knowledge Transfer Partnership, 3D Bioprinting technology for new market solutions in the UK. Participants: University of Essex and iMakr Group 2022-2024
PI Marie Skłodowska-Curie Individual Fellowship (EU-H2020-MSCA-IF), STOICISM - Stochastic Communication Inside Cortical Microcolumns 2019-2022
PI WIT President PhD Funding, Internet of Nano Things for the Next Generation Theranostics of Brain Glioblastomas 2019-2023
Co-I EU-H2020-FET. GLADIATOR: Next-generation theranostics of brain pathologies with autonomous externally controllable nanonetworks 2018-2022
PI Enterprise Ireland Commercialisation Fund, CDaaS – Clinical Data as a Service 2018-2019
PI Irish Research Council, Government of Ireland Postdoc Fellowship, Application of Control Theory in Molecular Communication for the Treatment of Alzheimer’s Disease 2016-2018

Recent Highlights

The Intersection Between the Biological and Digital – Advancing Synthetic Biological Intelligence and Organoid Intelligence.
View publication on Frontiers in Cellular Neuroscience

Digital twins of tissues and organs: in silico pharmacology from multiscale biophysics to clinical insight.
Read full article on IEEE Xplore

Appointed Co-Lead of the Special Interest Group on Learning the Organisational Principles of Living Systems.
View the SIG page on the Turing website, GET INVOLVED!

Join Us

Students: PhD projects in living computation and regenerative biohybrids – apply now.

Collaborators: We welcome partnerships with clinicians, device engineers, and ethicists. Let’s build the future of biohybrid systems together – contact us.

Open Science: Explore our code, datasets, and tools on GitHub.